使用Tofts,修改-Tofts和费米函数模型对15O水PET进行量化 perfusion CMR的验证,采用解卷技术
Masafumi Takafuji1, Masaki Ishida1, Yasutaka Ichikawa1
1Department of Radiology and Mie University Hospital, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
概括
定量输液心血管磁共振 (QP-CMR) 与O-水PET相比,准确地绘制心肌血流 (MBF) 的地图. 费米函数和托夫特斯模型显示了检测异常 perfusion 的实际优势.
科学领域:
- 心血管成像 - 心血管成像
- 医学物理 医学物理
- 放射学 放射学是一门学科.
背景情况:
- 定量输液心血管磁共振 (QP-CMR) 使用各种解卷模型提供像素智能的心肌血流 (MBF) 映射.
- 对于人类的MBF映射,QP-CMR的准确性需要进一步的研究.
- 这项研究验证了先进的QP-CMR技术与O-水正子发射断层扫描 (PET) 相比.
研究的目的:
- 评估先进的QP-CMR技术对心肌动脉血流量 (MBF) 量化的准确性.
- 为了比较由QP-CMR与15O水PET衍生出的MBF和心肌 perfusion reserve (MPR).
- 评估QP-CMR在检测异常心肌 perfusion 的诊断性能.
主要方法:
- 怀疑冠状动脉疾病的39名患者接受了压力/休息QP-CMR和15名O水PET.
- 使用Tofts,修改Tofts和费米函数解卷模型生成MBF地图.
- 使用相关性,布兰德-阿尔特曼,ICC和ROC分析来评估一致性和诊断准确性.
主要成果:
- 对于所有模型 (r=0.752-0.784),QP-CMR显示与15O水PET具有良好的线性相关性.
- 对MBF的测量偏差在0.05±0.63到0.31±0.70毫升/分钟/克之间.
- 与修改后的托夫特模型相比,托夫特和费米函数模型在检测异常输液方面表现出更高的ROC性能.
结论:
- 先进的QP-CMR技术显示出与15O水PET在MBF量化方面的强烈一致.
- 费米函数和托夫特斯模型在识别异常心肌输液方面更有效.
- 费米函数模型由于其精度与技术可用性的平衡,提供了实际优势.
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