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Updated: Jan 7, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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可追踪小鼠TNBC模型捕捉了异质瘤免疫微环境和适应PD-L1阻塞的情况

Robbe Salembier1,2, Caro De Haes1,2, Kristel Demeyere1

  • 1Laboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

NPJ breast cancer
|December 26, 2025
PubMed
概括

三重阴性乳腺癌 (TNBC) 对免疫治疗的反应有所不同. 鼠标模型显示,免疫抑制性髓状细胞和与癌症相关的纤维细胞驱动对PD-L1阻塞的抵抗,无论瘤炎症如何.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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