优化的并发症指数可以反映前列腺癌基于登记册的研究中的患者表现状况
Marcus Westerberg1,2, Hans Garmo3, Jesper Bonnedahl4
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. marcus.westerberg@uu.se.
Scientific reports
|December 26, 2025
概括
患者年龄和新的并发症指数可以有效地替代前列腺癌研究中的东部合作性瘤组绩效状态 (ECOG-PS). 这种方法有助于识别使用医疗保健登记册进行临床研究的合适患者队列.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 医疗信息学 医疗信息学
背景情况:
- 东方合作瘤组绩效状况 (ECOG-PS) 对于癌症试验资格至关重要,但在医疗保健登记中经常缺失.
- 在没有 ECOG-PS 数据的情况下,为基于注册的研究选择合适的患者群体是具有挑战性的.
研究的目的:
- 评估患者年龄和并发症指数是否可以替代ECOG-PS在基于高级前列腺癌登记册的研究中选择男性.
- 开发和验证用于使用常规可用的数据预测ECOG-PS状态的模型.
主要方法:
- 利用来自瑞典前列腺癌数据库的3966名男性进行前列腺癌的雄激素剥夺治疗的数据.
- 使用后勤回归模型来区分ECOG-PS 0-1和2-4使用年龄,查尔森并发症指数 (CCI),基于多维诊断的并发症指数 (MDCI) 和药物并发症指数 (DCI).
主要成果:
- 结合年龄,MDCI和DCI的模型显示出最好的歧视,AUC为0.82 (95%CI为0.81-0.84).
- 这种模型可以准确地识别那些可能具有有利的ECOG-PS的男性,显著减少那些具有更高ECOG-PS (2-4) 的男性在假设队列中的纳入.
结论:
- 患者年龄,MDCI和DCI可以作为高级前列腺癌基于登记册的研究中ECOG-PS的可靠替代品.
- 这些发现有助于识别具有有利绩效状态的研究人群,提高了医疗保健登记册在癌症研究中的实用性.
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