探讨脉冲波速度和CKD进展之间的关联:伊朗马什哈德的一项纵向研究
Susan Darroudi1, Naiemeh Varasteh1, Hayder Taha Yaseen2
1Vascular and Endovascular Surgery Research Center, Mashhad University of medical sciences, Mashhad, 99199-91766, Iran.
Scientific reports
|December 26, 2025
概括
动脉硬度,通过脉冲波速度 (PWV) 测量,是功能下降的重要指标. 增加PWV与降低估计的淋巴细胞过率 (eGFR) 相相关,突出其在慢性病进展中的作用.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
背景情况:
- 动脉硬是功能衰竭的新兴血管风险因素.
- 对动脉硬性的非侵入性评估为了解脏疾病提供了一种新的方法.
- 动脉硬与慢性病 (CKD) 之间的关系需要进一步调查.
研究的目的:
- 评估非侵入性动脉硬度测量和减少膜过率 (GFR) 之间的相关性.
- 调查动脉硬性标志物与慢性病 (CKD) 的不同阶段之间的关联.
主要方法:
- 伊朗MASHAD研究中787名参与者 (35-65岁) 的队列研究.
- 使用脉冲波速度 (PWV),中央增强指数 (CAI) 和中央大动脉压力 (CAP) 评估动脉硬度.
- 根据估计的GFR (eGFR) 水平,参与者被分为四组.
主要成果:
- 脉冲波速度 (PWV) 随着估计GFR (eGFR) 的下降而显著增加,特别是在最低的eGFR组 (组4) 中.
- 在较高的PWV和高级CKD阶段 (组4) 之间发现了显著的相关性.
- 经过调整后,PWV的每个单位增加都与eGFR的41.8%下降有关.
结论:
- 动脉硬,特别是PWV,是功能恶化的重要标志物.
- PWV与降低的eGFR独立相关,强调其在CKD中的作用.
- 建议进一步研究将动脉硬与功能受损联系在一起的机制.
相关概念视频
01:25Chronic Kidney Disease I: Introduction
536
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
536
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
166
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
166
01:28Chronic Kidney Disease III: Interprofessional Care
319
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
319
01:18Chronic Kidney Disease IV: Nursing Management
287
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
287
01:29Acute Kidney Injury III: Clinical Manifestations
763
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
763