双酸盐对眼睛的不良影响和与骨髓缩的关联来自现实世界的数据库
Samuel H Kim1,2, Ehsan Rahimy2,3, Euna B Koo2
1Medical Scientist Training Program, Stanford University School of Medicine, Palo Alto, CA, USA.
Eye (London, England)
|December 26, 2025
概括
具有眼部不良影响 (OAEs) 的双酸盐使用者面临更高的骨硬化风险. 与口服形式相比,静脉注射双酸盐增加了OAE (如干眼) 的可能性.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学 是一个学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 双酸盐是骨质疏松症的标准治疗方法.
- 眼部不良影响 (OAEs) 和系统性风险,如骨质死结,在大量人群中没有得到充分研究.
- 了解与双酸盐相关的OAE对于患者的安全至关重要.
研究的目的:
- 调查双酸盐诱导的OAEs与骨硬化风险之间的关联.
- 为了比较口服和静脉输入双酸盐的OAE率.
- 在一个大而多元的患者群体中分析OAE.
主要方法:
- 一个跨国电子健康记录数据库的回顾性分析.
- 纳入标准:没有先前的OAE,双酸盐处方和后续访问.
- 倾向性得分与混因子对照相匹配;基于双酸盐路线的OAE率的比较.
主要成果:
- 分析了944,559名患者 (平均年龄75岁) 的队列.
- 其中OAE包括眼睛干燥 (1.73%),眼睛表面炎症 (0.97%) 和眼膜炎 (0.17%).
- 患有OAE的患者表现出骨髓折的风险增加 (RR: 1.48),特别是使用佐莱德酸 (RR: 2.22). 静脉注射双酸盐增加了干眼风险 (RR: 1.27).
结论:
- 与OAEs一起使用双酸盐与较高的骨质死结的风险有关,即使比以前建议的更少.
- 与口服配方相比,静脉注射双酸盐与OAE的风险更大.
- 眼科医生应监测使用双酸盐的患者的OAE和相关的全身风险.
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