在轻度认知障碍中对重金属和微量元素进行系统审查和元分析
Yaxin Dong1, Lu Ren1, TianRan Tang2
1Shanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Biological trace element research
|December 26, 2025
概括
某些重金属和微量元素的含量在轻度认知障碍 (MCI) 患者中不同. 监测这些因素可能为神经退行性疾病的早期干预提供新的策略.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 生物化学 生物化学
背景情况:
- 轻度认知障碍 (MCI) 是神经退行性疾病的早期阶段.
- 在MCI患者中,重金属和微量元素水平存在显著的异质性.
- 了解这些基本差异对于早期诊断和干预至关重要.
研究的目的:
- 系统地审查和对MCI患者的重金属和微量元素水平的研究进行元分析,与健康对照进行比较.
- 在MCI中识别有变化的度的特定元素.
- 根据元素概况,探索潜在的诊断或治疗目标.
主要方法:
- 在PubMed,科学网和中国学术数据库 (2000年至今) 的系统文献搜索.
- 包括43个病例控制/横截面研究,涉及16743个样本.
- 使用随机效应模型计算12个元素的标准化平均差异 (SMD) 的元分析.
主要成果:
- 在MCI患者中观察到 (Al), (As), (Cd),铜 (Cu) 和 (Pb) 的水平升高.
- 在MCI患者中发现 (Se) 和 (Zn) 的水平明显较低.
- 在铁 (Fe) 和 (Mg) 等方面没有发现显著差异.
结论:
- 特定的重金属和微量元素配置与轻度认知障碍有关.
- 变化的Al,As,Cd,Cu,Pb,Se和Zn水平表明它们在MCI病原发生过程中的潜在作用.
- 监测和调节这些元素水平可能代表神经退行性疾病早期干预策略的新目标.
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