变化的动态功能连接性与不同程度的白质超强度认知相关
Tianyuyi Feng1, Yunfei Li1, Chunxiao Wei2
1The Department of Radiology of the Fifth People's Hospital of Shanghai, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.
BMC medical imaging
|December 26, 2025
概括
白质过强度 (WMH) 的严重程度会随着时间的推移影响大脑连接模式,可能与认知功能有关. 需要进一步的研究来证实这些发现在更大的患者群体.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 白质高强度 (WMH) 在脑小血管疾病 (CSVD) 中很常见.
- WMH严重程度对动态功能连接 (DFC) 的影响及其与认知障碍的关系仍然不清楚.
研究的目的:
- 为了研究不同严重程度的WMH患者的DFC模式.
- 探索与WMH严重程度有关的DFC时间性质和认知功能之间的关联.
主要方法:
- 85名CSVD患者接受了MRI扫描和神经心理测试.
- 使用滑窗相关性和k-means聚类来分析DFC,以识别不同的大脑状态.
- 计算了DFC的时间性质 (停留时间,分数窗口,过渡数).
主要成果:
- 在轻度和严重的WMH组中,确定了四种不同的DFC状态.
- 与轻度WMH患者相比,严重WMH患者在低连接状态中花费的时间更长,在超连接状态中花费的时间更少.
- DFC的时间性质显示出与执行功能和WMH严重性的探索性相关性.
结论:
- WMH的严重程度会影响DFC的时间动态,这表明与认知缺陷的潜在联系.
- 这些发现是探索性的,需要在更大的多中心研究中进行验证.
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