呈现双关节狭窄症的多炎的ANCA-阴性埃索诺菲尔粒状瘤:一个病例报告
Jiajia Chen1, Jiajun Liu2, Min Luo3
1Department of Respiratory and Critical Care Medicine, The People's Hospital of Rongchang District, Chongqing, China.
The American journal of case reports
|December 27, 2025
概括
带有多炎 (EGPA) 的埃索诺菲尔颗粒瘤可以导致十二指甲管狭窄,这是一个罕见的胃肠道并发症. 早期诊断和免疫抑制治疗对于在患有eosinophilia的喘患者中管理这种严重表现至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 带有多炎 (EGPA) 的异性粒状炎是一种罕见的ANCA相关的血管炎.
- 胃肠道并发症,如十二指肠狭窄,在EGPA中不常见.
研究的目的:
- 报告一个EGPA病例,表现为十二指甲管狭窄.
- 要强调考虑EGPA在患有无法解释的胃肠道阻塞和eosinophilia的患者的重要性.
主要方法:
- 一个71岁的男性患有喘和胃肠道症状的病例报告.
- 诊断工作包括电子胃镜检查,病理学和排除其他乙酸性疾病.
- 治疗包括甲基prednisolone和环胺.
主要成果:
- 这位患者出现了十二指甲球泡狭窄和显著的乙素透.
- 根据系统性标准诊断出EGPA,尽管ANCA是负面的.
- 治疗导致症状缓解,炎症标志物的正常化,并改善了十二指肠狭窄.
结论:
- 十二指甲管狭窄可能是EGPA的罕见但严重的表现,由eosinophilic炎症驱动.
- 在患有胃肠道阻塞和eosinophilia的喘患者中应考虑EGPA.
- 早期的免疫抑制疗法和内镜评估对于有利的结果至关重要.
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