在毒性中通过天然化合物向铁死:一篇评论
Fatemeh Darvishzadeh Mahani1, Azhdar Heydari2, Reihaneh Sadeghian3
1Physiology Research Center, Institute for Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Journal of biochemical and molecular toxicology
|December 27, 2025
概括
自然化合物保护脏免受毒性损伤,通过减少铁亡,这是一种涉及铁和氧化应激的细胞死亡途径. 这些化合物调节关键通路,以防止毒剂对损伤.
科学领域:
- 生物化学 生化学
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 毒性,毒素对脏造成的损伤,可以导致急性或慢性损伤.
- 铁,一种依赖于铁的细胞死亡,因脂质过氧化物积累而涉及毒性病原体.
- 像黄素,素和白素这样的天然化合物显示出减轻损伤的潜力.
研究的目的:
- 审查天然化合物对毒性的保护作用.
- 阐明自然化合物在损伤模型中抑制铁亡的机制.
- 突出自然化合物的向途径调节在不同的毒性背景下.
主要方法:
- 对研究天然化合物和毒性研究的文献综述.
- 分析涉及铁灭的分子途径,并通过天然化合物对它们进行调制.
- 对不同毒药物 (如思丁,阿德里亚米辛) 的铁灭机制进行比较.
主要成果:
- 自然化合物增强保护通路 (GPX4,Nrf2 / GPX4,SIRT1 / p53) 对铁死.
- 这些化合物抑制有害的通路 (Hippo,HIF-2α/DUOX1/GPX4,ERK1/2,ALOX12,费里丁).
- 铁亡机制与毒药物不同,需要有针对性的天然化合物干预.
结论:
- 自然化合物为脏保护提供了一个有前途的治疗策略.
- 通过天然化合物减轻铁亡是预防毒性的关键机制.
- 基于特定ferroptotic通路的自然化合物的有针对性的应用显示出治疗损伤的潜力.
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