捐赠者放射性肺炎对移植后接受者结果和微生物学影响
Kevin D He1,2, Susanna M Leonard2,3, Alyssa Mezochow1,2
1Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
概括
在肺移植中,捐赠者的放射性肺炎 (DRP) 是常见的,并且与更长的住院时间有关. 然而,它不会影响长期存活率或显著增加移植后肺炎风险.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 放射学 放射学是指放射学
背景情况:
- 扩展标准供体肺,包括有胸部放射 (CXR) 异常的肺,在肺移植中越来越多地使用.
- 对于接受肺移植的供体放射性肺炎 (DRP) 的临床意义尚不清楚.
研究的目的:
- 为了研究捐赠者的放射性肺炎 (DRP) 对肺移植接受者的影响.
- 为了比较接收者接受带有DRP和没有DRP的肺之间的结果.
主要方法:
- 2019年1月1日至2023年8月1日期间进行的肺移植的单中心回顾性队列研究.
- 纳入标准要求对肺炎模式进行可解释的供体胸部成像 (CXR或计算机断层扫描侦察器).
- 在DRP和非DRP组之间比较了结果和微生物特征.
主要成果:
- 在包括肺移植患者的154人中,57.1%患有DRP,58.4%有积极的预采购捐赠者呼吸道培养物.
- 接受DRP的患者在医院住院时间较长 (LOS) (25.5 vs. 20天,p=0.04).
- 在接受者呼吸器时间或ICU LOS中没有发现显著差异;16.9%的接受者患上了移植后肺炎.
结论:
- 捐赠者的放射性肺炎与肺移植接受者的医院LOS增加有关.
- DRP似乎不会影响肺移植后的长期生存.
- 虽然呼吸道病原体经常从供体肺部分离出来,但这可能与移植后肺炎的发展没有直接关联.
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