与病毒相关的肝细胞癌的免疫疗法:最近的进展和未来的方向
Ruijuan Song1, Mingyuan Li1, Shengqiang Tang1
1Anhui Hospital of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Hefei, Anhui Province, China.
Annals of medicine
|December 27, 2025
概括
肝细胞癌 (HCC) 免疫疗法对与病毒相关的癌症具有前景. 结合免疫检查点抑制剂与抗病毒疗法和生物标志物的个性化策略是获得更好的结果的关键.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 肝细胞癌 (HCC) 是全球主要的癌症杀手,主要是由乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 感染引起的.
- 慢性病毒感染驱动HCC的发展,改变肝脏的免疫环境,影响免疫治疗的有效性和安全性.
研究的目的:
- 审查病毒相关HCC免疫治疗的最新进展和未来前景.
- 突出综合管理策略对于优化治疗结果的重要性.
主要方法:
- 关于免疫检查点抑制剂 (ICI) 和HCC的组合疗法的当前文献的综述.
- 探索新兴的治疗方法,包括新的免疫检查点,细胞疗法和疫苗.
- 讨论针对个性化治疗选择的生物标志物发现方面的进展.
主要成果:
- 免疫检查点抑制剂 (PD-1/PD-L1) 在晚期HCC中显示出临床益处.
- 组合策略 (ICI与抗血管生成药等) 和抗病毒疗法对于与病毒相关的HCC至关重要.
- 下一代免疫疗法和生物标志物引导的方法正在研究中.
结论:
- 免疫疗法为与病毒相关的HCC提供了希望,但在响应变异性和耐药性方面面临挑战.
- 综合免疫疗法,抗病毒管理和生物标志物的个性化治疗计划是必不可少的.
- 对病毒-免疫-瘤相互作用的进一步研究将改善HCC治疗的疗效和耐久性.
更多相关视频
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
1.7K
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.9K
相关概念视频
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Vaccines
917
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
917
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Microorganisms in Medicine and Therapeutics
908
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
908
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Mechanisms of Retrovirus-induced Cancers
6.8K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.8K
