多发性硬化症中的过敏现象和喘:流行病学和遗传关系
Farren Briggs1, Anda Nyati2, Sophia Zweig3
1Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
概括
多发性硬化症 (MS) 与较少的季节性过敏有关. 多发性硬化症的遗传因素也会影响患有多发性硬化症的人的过敏风险.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 和过敏性疾病 (AD) 传统上被视为免疫学上不同的疾病.
- 以前的研究表明,MS和AD之间存在潜在的反向关联和共同的遗传影响.
研究的目的:
- 为了比较患有多发性硬化症 (PwMS) 的人群中喘和过敏现象的患病率与对照人群.
- 为了检查在不同的MS临床课程中AD的流行率.
- 为了研究MSMS中的遗传风险因素 (HLA-DRB1*15:01,遗传风险评分) 和ADs之间的关联.
主要方法:
- 来自1542个PwMS和700个对照的调查和基因型数据的分析.
- 对混因素进行了调整后勤回归模型.
- 在1252 PwMS中进行遗传分析,以评估HLA-DRB1*15:01和非MHC遗传风险评分 (GRS) 对ADS的影响.
主要成果:
- 与对照组相比,患有多发性硬化症 (PwMS) 的人患季节性过敏的几率较低 (OR=0.79).
- 在初级进展性MS与复发性MS (OR=0.58) 中观察到减少AD患病率的非显著趋势.
- 在PwMS中,HLA-DRB1*15:01与增加质过敏的几率有关,而GRS显示与儿童开始的季节性过敏有相反的关联.
结论:
- 多发性硬化症与季节性过敏的发病率降低有关.
- 多发性硬化症的遗传风险因素似乎会调节患有这种疾病的个体的过敏敏感性.
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