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性对患有复杂先天性心脏病的婴儿皮质改变的影响

Xuyun Wen^1,2, Pengcheng Xue^1,2, Siyu Ma³

¹Department of Intelligent Interdisciplinary Applications, College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Jiangjun Road, Jiangning District, Nanjing 211106, Jiangsu, China.

Cerebral cortex (New York, N.Y. : 1991)

|December 27, 2025

概括

与女性相比,患有先天性心脏病 (CHD) 的男性婴儿表现出更大的脑容量减少和运动技能缺陷. 了解这些性别差异对于开发针对性神经保护策略对于心脏病患者至关重要.

科学领域:

神经科学是一个神经科学.
儿科儿科儿科
发展生物学发展生物学

背景情况:

先天性心脏病 (CHD) 显著影响神经发育结果.
性是一个关键因素,男性经常表现出更严重的损伤.
有限的研究存在于性特异性早期大脑发育在患有心脏病的婴儿.

研究的目的:

调查复杂先天性心脏病的婴儿对大脑发育的性别特异性影响.
为了确定男性和女性CHD婴儿之间全球和区域大脑变化的独特模式.
为了将大脑发育差异与神经发育结果相关联.

主要方法:

从79名患有复杂心脏病的婴儿 (42名男性,37名女性) 和87名健康对照 (47名男性,40名女性) 收集磁共振成像 (MRI) 数据.
全球和区域大脑体积,皮质厚度,灰质体积和表面积的分析.
统计分析以检查性别特异性影响和与神经发育评估的关联.

主要成果:

男性心血管疾病婴儿显示全球大脑体积减少和区域皮质延迟 (厚度增加,灰质体积增加).
女性心血管疾病婴儿显示局部异常 (表面积减少,厚度增加) 没有显著的总体体积变化.
男性的全球大脑体积减少与较差的毛细运动技能相关.

结论:

在患有先天性心脏病的婴儿中,大脑发育中的显著性别差异在生命早期显而易见.
这些独特的神经解剖学模式凸显了在治疗心血管疾病方面需要性别特定的方法.
定制的神经保护策略对于优化CHD人群的神经发育结果至关重要.

关键词:

大脑发育大脑的发育大脑的发展遗传性心脏病是一种先天性心脏病.婴儿婴儿婴儿婴儿神经发育的结果.在性爱中,性爱是性爱.

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