菌毒素和非传染性疾病:恶化和易感性
Bingxin Huangfu1, Yanan Chen2, Tongxiao Xu1
1Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, PR China.
食物中的真菌污染物菌毒素与癌症和代谢障碍等非传染性疾病有关. 需要进一步的研究来了解这些环境触发因素,并保护弱势群体.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 菌毒素是真菌的二次代谢物,作为环境污染物.
- 它们污染了谷物,水果和坚果等主食,进入人类的饮食中.
- 关于真菌毒素与慢性疾病的联系存在有限的系统审查.
研究的目的:
- 总结目前关于真菌毒素在非传染性疾病 (NCD) 进展中的作用的证据.
- 探索特定的真菌毒素 (脱氧尼瓦伦醇,T-2毒素,帕图林,氨酸) 及其相关的非传染性疾病.
- 为了确定毒素-NCD相互作用中的潜在机制和宿主易感性.
主要方法:
- 对现有的科学文献进行系统审查.
- 分析证据,将特定的真菌毒素与各种非传染性疾病联系起来.
- 识别导致的因素,如肠道屏障功能和代谢失调.
主要成果:
- 菌毒素被认为是非传染性疾病的环境触发因素,包括癌症,代谢,胃肠道,神经退行性,行为,生殖和甲状腺疾病.
- 患有非传染性疾病的个体可能对真菌毒素影响的敏感性增加.
- 肠道屏障功能受损和代谢失调是潜在的促成因素.
结论:
- 菌毒素是非传染性疾病的重要环境风险因素.
- 进一步的研究对于阐明机制和制定食安全指南至关重要.
- 对暴露于真菌毒素的脆弱人群需要有针对性的干预措施.
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