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Updated: Jan 7, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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改变的B细胞代谢途径标志着1型糖尿病的进展

Holly Conway1,2, Jessica Bernard1,2, Rachel Ramos1,2

  • 1Department of Pediatrics, Division of Pediatric Endocrinology, Indiana University School of Medicine, Indianapolis, IN, United States.

Journal of immunology (Baltimore, Md. : 1950)
|December 27, 2025
PubMed
概括

调控性B细胞 (Bregs) 对于预防1型糖尿病 (T1D) 至关重要. 在这项研究中,NOD小鼠B细胞显示代谢发生变化,HIF-1α减少,影响IL-10的产生和免疫耐受性.

关键词:
B 细胞细胞B 细胞细胞缺氧 缺氧是指缺氧的情况.免疫代谢的免疫代谢.第1类糖尿病 1型糖尿病

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