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银纳米颗粒涂层对周围植入物粘膜和微生物群的影响
Ryutaro Ito1, Yusuke Taniguchi1, Tadahiro Kashiwamura1
1Section of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, Fukuoka, Japan.
International journal of implant dentistry
|December 27, 2025
概括
牙植入物的银纳米粒子 (AgNP) 涂层通过改变周围植入物微生物组,改善了牙健康,减少了恶臭. 这种创新的AgNP处理为植入物维护和气味控制提供了有前途的方法.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 牙周病学 牙周病学
背景情况:
- 牙植入物容易受到植入周围微生物组失调,导致牙炎症和恶臭.
- 目前的植入物维护策略可能无法完全解决微生物组变化和相关并发症.
研究的目的:
- 为了研究银纳米粒子 (AgNP) 涂层对植入物超结构的影响.
- 为了确定AgNP涂层是否会改变周围植入物微生物组的组成.
- 评估牙状况的改善和恶臭抑制.
主要方法:
- 这是一项单盲比较研究,涉及19名接受植入物维护的患者.
- 实验组接受了超声波清洗后的AgNP涂层;对照组仅接受了超声波清洗.
- 评估包括修改的牙指数 (mGI),有机感/嗅觉测量气味分析,以及在基线和3个月的周围植入物微生物组概况.
主要成果:
- 与对照组相比,AgNP治疗组的mGI值显著下降 (p=0.043).
- 体感测试显示,实验组的气味概况发生了变化,PCA显示了气味模式的变化.
- 微生物组分析显示,在AgNP组中,Neisseria oralis和Ottowia的相对丰度增加,Veillonella parvula,Fretibacterium fastidiosum和Tannerella forsythia的丰度减少.
结论:
- AgNP涂层有效地改变了植入周围微生物组的组成.
- 观察到的微生物组转变与改善的牙健康有关.
- 采用AgNP涂层,可以在周围植入物组织中产生除臭作用.
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