揭开乳腺癌风险,重点关注更年期状态:一项大型病例对照研究
Jini Sara Jacob1,2, Preethi Sara George2, Beela Sarah Mathew3
1Research Scholar, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Cancer causes & control : CCC
|December 27, 2025
概括
生活方式和遗传学显著影响乳腺癌 (BC) 风险. 饮食和体力活动等可改变的因素至关重要,特别是在绝经后的妇女中,突出了针对性预防策略的必要性.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 是一个重要的全球健康问题.
- 风险受到生活方式 (可修改) 和遗传 (不可修改) 因素的影响.
- 了解这些因素是有效预防策略的关键.
研究的目的:
- 评估可修改和不可修改风险因素对南印度妇女乳腺癌 (BC) 的影响.
- 单独分析这些影响对于绝经前和绝经后的妇女.
- 为针对性乳腺癌预防策略提供信息.
主要方法:
- 一个大型,基于人群的,年龄相匹配的病例控制研究.
- 涉及来自印度喀拉拉邦 (2017-2023) 的3043例新诊断的乳腺癌病例和对照.
- 使用条件逻辑回归分析流行病学风险因素,使用几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 频繁的炸食物消费,身体不活动和高的BMI是BC整体显著的可修改风险因素.
- 非可改变的因素,如良性乳腺疾病,以前的胸部辐射,农药暴露和家族病史也增加了BC风险.
- 分层分析揭示了绝经前和绝经后妇女的不同风险因素概况,而绝经后的个人更关键的是可修改的因素.
结论:
- 在更年期组中,不可修改的因素始终影响乳腺癌风险.
- 可改变的因素,特别是饮食和体育活动,在乳腺癌的发展中起着关键作用,特别是在绝经后的妇女中.
- 促进体育活动和体重管理可以显著降低乳腺癌风险.
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