在饮料中摄入薄荷醇可能会改变在被动热应激期间的出汗反应,但只有当饮料冷时才能改变
Mackenzie Nelson1, KarLee Lefebvre1, Douglas Newhouse1,2
1School of Kinesiology, Lakehead University, Thunder Bay, Ontario, Canada.
Journal of applied physiology (Bethesda, Md. : 1985)
|December 27, 2025
概括
在热应激期间食用冷液体和薄荷醇可以改变出汗反应. 物理冷却与TRPM8 (过渡受体潜力 melastatin 8) 的化学激活相结合,是影响热调节出汗的必要条件.
科学领域:
- 身体生理学 身体生理学
- 热调节 热调节 热调节
- 环境健康 环境健康
背景情况:
- 在热应激期间饮用冷液体会影响出汗.
- 化学激活冷敏瞬态受体潜力 melastatin 8 (TRPM8) 在温度调节中的作用尚未完全理解.
- 动物模型表明TRPM8激活需要物理冷却以影响热效应器反应.
研究的目的:
- 研究物理冷却和化学TRPM8激活对热调节性出汗的综合作用.
- 为了确定薄荷醇,TRPM8激动剂,在被动热应激期间改变出汗反应,当与冷或温暖的液体一起摄入时.
主要方法:
- 十二名健康参与者在随机顺序下接受了四个被动加热协议.
- 参与者在加热前和加热期间消耗了37°C的水,1.5°C的水,37°C的薄荷醇溶液或1.5°C的薄荷醇溶液.
- 在前臂和额头上测量出汗的开始,汗液运动热敏度和出汗率.
主要成果:
- 与热液体 (37°C) 相比,冷液体消耗 (1.5°C) 减弱了前臂出汗的发作和热运动热敏度.
- 薄荷醇的摄入延迟了前臂出汗的开始,但没有影响运动热敏度.
- 用冷薄荷溶液在0.5°C的直肠温度上升时观察到小幅减轻出汗率,但在1.0°C时没有.
结论:
- 在胃肠道中TRPM8的化学激活可以影响热调节性出汗,但只有当与物理冷却相结合时.
- 观察到冷液和薄荷醇对出汗的作用是温和的.
- 需要进一步的研究,以充分阐明TRPM8在人类温度调节中的机制.
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