系统性硬化症中手部功能障碍:通过对临床,放射和超声波特征的调查确定因素
Giulia Franchi1, Elena Marazzi2, Alain Lescoat3
1Department of Internal Medicine and Therapeutics, Università di Pavia, Italy; Fondazione IRCCS Policlinico San Matteo, Department of Rheumatology, Pavia, Italy; Department of Rheumatology, Assistance Publique-Hôpitaux de Paris, Cochin Hospital, Université Paris Cité, Paris, France.
Seminars in arthritis and rheumatism
|December 27, 2025
概括
系统性硬化症 (SSc) 患者
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 肌肉骨疾病 肌肉骨疾病
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病.
- 手部功能障碍显著影响SSc.患者的生活质量.
- 皮肤,血管和肌肉骨 (MSK) 因素是已知的SSc相关手部功能障碍的贡献者.
研究的目的:
- 调查皮肤,血管和MSK干扰对SSc患者手部功能的影响.
- 评估临床,放射和超声波 (美国) 特征与患者报告的手部功能结果 (PROs) 相对应.
- 在现实世界SSc队列中确定手部残疾的关键预测因素.
主要方法:
- 一个多中心的,横截面的研究设计.
- 包括140名SSc患者,评估了临床,放射和美国特征.
- 对于PRO和外部验证数据,使用了Cochin Hand功能尺度 (CHFS).
主要成果:
- CHFS得分与修改后的罗丹恩皮肤得分 (mRSS) 和美国检测到的紧肌炎有显著的相关性.
- 观察到与硬化模式紧突炎和结症相关的趋势.
- 多变量分析证实皮肤纤维化和紧突炎是手部残疾的重要预测因素.
结论:
- 在SSc中手部功能障碍是多因素的,主要是由皮肤纤维化和MSK参与驱动的.
- 美国检测到的突肌炎是与手部残疾相关的关键因素.
- 超声波是评估SSc患者MSK疾病严重程度和活性的一个有价值的工具.
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