Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

4.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
4.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reply to Comment on: "Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson's Disease".

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Pallidal Deep Brain Stimulation in Dystonia: Investigating Differential Response by Dystonia Distribution.

Tremor and other hyperkinetic movements (New York, N.Y.)·2026
Same author

Decoding common and rare noncoding variant effects across cellular and developmental contexts.

Nature genetics·2026
Same author

Author Correction: Plasticity and language in the anaesthetized human hippocampus.

Nature·2026
Same author

Plasticity and language in the anaesthetized human hippocampus.

Nature·2026
Same author

Response to Satapathy et al.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026

相关实验视频

Updated: May 3, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.5K

运动唤起的潜力作为一种副作用生物标志物,用于深度大脑刺激.

Paola Testini1, Austin Wang2, Eric R Cole3

  • 1Department of Neurology, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84105, United States.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
|December 27, 2025
PubMed
概括

运动唤起的潜能 (MEP) 可以在深度大脑刺激 (DBS) 期间识别亚临床皮质球膜和皮质脊髓管激活. 这种生物标志物有助于检测帕金森病患者的运动副作用.

关键词:
皮质球膜管道 皮质球膜管道皮质脊椎管 脊椎管中的皮质脊椎管.帕金森病是帕金森氏症的一种疾病.表面的EMG是表面的EMG.

更多相关视频

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.0K
A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

15.3K

相关实验视频

Last Updated: May 3, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.5K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.0K
A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

15.3K

科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 临床神经学 临床神经学

背景情况:

  • 深度大脑刺激 (DBS) 是对帕金森病的一种治疗干预.
  • 在DBS编程期间识别和预测运动副作用对于患者的安全性和治疗疗效至关重要.
  • 目前用于评估DBS期间通道激活的方法可能不够敏感以检测亚临床变化.

研究的目的:

  • 调查运动唤起潜力 (MEP) 作为DBS期间皮质球膜 (CBT) 和皮质脊柱 (CST) 管激活的潜在生物标志物.
  • 在接受DBS的帕金森病患者中,将MEP值与临床运动副作用值相关联.

主要方法:

  • 包括12名帕金森病患者,患有亚thalamic或pallidal DBS.
  • 联系地图确定了临床运动副作用的值.
  • 电肌图 (EMG) 在特定的刺激参数下从头骨和手臂肌肉中记录了MEP.

主要成果:

  • 随着刺激强度的增加,MEP振幅会增加,头骨肌肉的延迟时间更短.
  • 在临床副作用和MEP值之间发现了显著的相关性 (R2=0.31,p=0.0006).
  • MEP值通常低于副作用值,表明亚临床通道激活,总体预测准确率为0.72.

结论:

  • 在DBS编程过程中,MEP值作为一种有价值的客观生物标志物用于检测运动副作用.
  • 这些发现表明,MEP可以揭示亚临床CBT/CST激活,提高DBS治疗的精度.
  • 这项研究突出了欧洲议会议员优化DBS参数选择和改善患者治疗结果的潜力.