基于生物信息学和实验验验证的头状细胞癌中与cuproptosis相关的基因的分析
Qunying Xu1, Chunli Li2, Aixia Zhao1
1Department of Oncology, Baise People's Hospital, Baise, 533000, China.
Biochemical and biophysical research communications
|December 27, 2025
概括
循环素依赖性激酶抑制剂2A (CDKN2A) 作为头部和部状细胞癌 (HNSCC) 的抑制基因. 低CDKN2A水平与预后不佳相关,它通过激活抗氧化剂信号来调解cuproptosis.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一个重要的全球健康问题.
- 了解推动HNSCC进展的分子机制对于开发有效疗法至关重要.
- 铜,一种依赖铜的细胞死亡途径,正在成为癌症生物学中的关键参与者.
研究的目的:
- 研究 cuproptosis 相关基因 (CRG) 在 HNSCC.中的作用和机制.
- 为了确定HNSCC的潜在诊断和治疗生物标志物.
- 阐明CRG对癌细胞行为的功能影响.
主要方法:
- 对HNSCC数据集的差异基因表达分析.
- 对差异表达基因的丰富分析和免疫透评估.
- 应用SHAP,GSVA和GSEA用于CRG识别和机制探索.
- 在实验室验证使用西部血栓检测,qRT-PCR和CCK-8试验.
主要成果:
- 鉴定出循环素依赖性激酶抑制剂2A (CDKN2A) 是一个关键的CRG和潜在的HNSCC生物标志物.
- 在HNSCC中CDKN2A的低表达与免疫反应和细胞周期调节相关.
- 与CDKN2A功能的干扰增强了癌细胞活性.
- 通过激活抗氧化剂保护信号,CDKN2A被证明可以调解cuproptosis.
结论:
- 在HNSCC中,CDKN2A作为瘤抑制基因起作用.
- CDKN2A具有作为HNSCC的诊断和治疗生物标志物的潜力.
- CDKN2A在激活抗氧化剂信号中的作用是其在HNSCC中调解质亡的核心.
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