在儿童癌症幸存者中,与输血相关的铁过载
Kiranmye Reddy1, Jonathan D Fish1, Jennifer Eng1
1Division on Pediatric Hematology / Oncology and Stem Cell Transplantation, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY, USA.
儿童癌症幸存者经常经历输血相关的铁过载. 提高费里水平可能可靠地表明铁负载,突出显示了对这一群体进行监测的需要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 输血相关的铁过载是接受多次输血的患者的一个重大问题.
- 儿童癌症幸存者 (CCS) 由于需要红细胞输血的强化癌症疗法而面临风险.
研究的目的:
- 确定CCS中输血相关的铁过载的患病率和严重程度.
- 在这个群体中调查铁过载的潜在指标和相关性.
主要方法:
- 通过血清铁研究和费里水平评估了75个CCS.
- 审查了血液银行记录,以检查包装红细胞 (pRBC) 的数量.
- 使用肝脏和心脏MRI,心声图和基因分析,用于满足特定标准的患者 (pRBC≥120mL/kg或费里≥1000μg/L).
主要成果:
- 15名患者 (40.5%的被评估患者) 患有中度至重度的肝脏铁过载 (肝脏铁度[LIC]>3 mg/g).
- LIC与pRBC总体体积和血清费里水平有很强的相关性.
- 没有检测到心脏铁负荷;遗传性血色素变异存在,但与铁过载无关.
结论:
- 与输血相关的铁过载在CCS中很普遍.
- 血清费里丁似乎是一个可靠的生物标志物,用于评估CCS中的铁负载.
- 这些发现强调了监测铁过载的重要性,因为癌症治疗可能会发生重叠的毒性.
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