在表面上自动构建心脏传播的相互连接的电缆模型
Elham Zakeri Zafarghandi1, Vincent Jacquemet1
1Pharmacology and Physiology Department, Institute of Biomedical Engineering, Université de Montréal, Montreal, QC, H3T 1J4, Canada; Institut Courtois d'Innovation Biomédicale, Université de Montréal, Montreal, QC, H3T 1J4, Canada; Hôpital du Sacré-Cœur de Montréal, Research Center, 5400 boul. Gouin Ouest, Montreal, QC, H4J 1C5, Canada.
Computer methods and programs in biomedicine
|December 27, 2025
概括
我们开发了一个自动化工具来生成心脏电缆网格模型,用于模拟电流传播. 这种开源软件包能够进行详细的,针对患者的心房建模,推进心脏电生理学研究.
科学领域:
- 计算生物学 计算生物学
- 心脏电生理学 心脏电生理学
- 生物医学工程 生物医学工程
背景情况:
- 心脏电传播通常使用相互连接的电缆网络进行建模.
- 缺乏用于生成这些电缆网格的自动化工具,阻碍了这种建模方法.
- 这项研究解决了对高效算法解决方案的需求.
研究的目的:
- 开发和评估一个开源的算法解决方案,用于自动生成电缆网格.
- 创建一个工具,用于构建单层互连的电缆模型,从三角形表面,定义纤维方向.
- 为了在心脏组织模型中实现电传播的模拟.
主要方法:
- 开发了一个开源的C++/Python包用于电缆网状结构.
- 使用的流线与纤维的方向对齐用于纵向连接.
- 用于横向连接的直角流线,定义网状顶点和连接.
- 在98个患者特定的几何形状上测试了管道,并评估了数值方案的稳定性.
主要成果:
- 在复杂的配置和近细胞分辨率 (20-200μm) 中验证了方法.
- 观察到光纤方向的不规则会影响局部合.
- 在患者特定几何形状的队列上证明了成功的网格生成.
- 与传统的网格类型相比,评估了数值稳定性.
结论:
- 开发的工具提供了一个基于生理学的网格生成方法.
- 这可以作为构建多层3D心房模型的基础组件.
- 有助于模拟心房中离散的电传播.
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