手术治疗对患有基本震的患者认知功能的影响
Vibhash D Sharma1, Diane S Berry2, Stephanie Cosentino3
1Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Journal of the neurological sciences
|December 27, 2025
概括
基本震 (ET) 手术,包括深度大脑刺激 (DBS) 和MR指导聚焦超声波 (MRgFUS),对整体认知的影响最小. 一些记忆和执行功能可能会随着时间的推移在手术患者中略有下降.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 认知科学 认知科学
背景情况:
- 基本震 (ET) 与认知能力下降有关,特别是随着年龄的增长.
- 深度大脑刺激 (DBS) 和MR指导聚焦超声波 (MRgFUS) 是ET的外科选择.
- 对于ET手术的长期认知影响还不太清楚.
研究的目的:
- 为了评估外科手术后ET患者的认知结果.
- 为了比较经过手术和没有手术的ET患者之间的认知功能.
主要方法:
- 对比了12名手术ET患者和188名非手术ET对照从一个纵向研究.
- 在36个月和54个月的间隔内评估手术前和手术后的认知功能.
- 采用混合模型对协差的分析,对年龄,教育和基线认知进行控制.
主要成果:
- 两组人都经历了适度的认知衰退.
- 在手术和非手术ET组之间发现了很少的显著整体认知差异.
- 手术组在特定记忆和执行功能子域中出现了较大的下降.
结论:
- ET手术干预 (DBS,MRgFUS) 并没有广泛影响老年患者的全球认知能力.
- 某些认知领域,特别是记忆和执行功能,可能在ET手术后更容易受到下降的影响.
- 需要进一步的研究,以了解ET手术后的细微认知变化.
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