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可吸收的微球维持epirubicin和TLR7激动剂释放用于肝脏瘤的跨动脉化疗免疫栓塞

Yan Wang¹, Jiakun Guo¹, Di Hu²

¹Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Journal of controlled release : official journal of the Controlled Release Society

|December 27, 2025

概括

新的可吸收微球为肝脏瘤提供化疗和免疫疗法,从而导致瘤完全回归并通过激活抗癌免疫反应来预防转移.

科学领域:

在瘤学瘤学.
生物材料科学生物材料科学
免疫学免疫学免疫学

背景情况:

跨动脉化学栓塞 (TACE) 是用于不可切除的肝脏瘤的标准治疗方法.
目前的TACE方法受到药物释放控制不佳和免疫抑制瘤微环境的影响.
需要改进治疗策略,以提高TACE的疗效,克服瘤诱导的免疫抑制.

研究的目的:

开发和评估新型可吸收微球载有epirubicin和imiquimod (EPI/IMQ@Asphere) 进行跨动脉化学免疫栓塞 (TACIE).
为了评估EPI/IMQ@Asphere的受控药物释放动力学.
在临床前肝癌模型中研究TACIE的治疗疗效和免疫调节作用.

主要方法:

合成和表征EPI/IMQ@Asphere,旨在控制释放epirubicin (EPI) 和imiquimod (IMQ) 的设计.
药物释放概况的体外评估,表明EPI持续释放超过4周,IMQ超过1周.
在体内评估TACIE使用EPI/IMQ@Asphere在小鼠和子的皮下H22和正位VX2肝脏瘤模型中.

主要成果:

EPI/IMQ@Asphere证明了化学疗法和免疫疗法剂的稳定储存和受控的顺序释放.
在H22模型中,单剂量TACIE导致5/7小鼠的瘤完全回归,具有持久的抗再挑战性,表明强大的免疫记忆.
在VX2模型中,TACIE显著减少了原发性瘤大小,并完全阻止了肺转移,伴随着内CD8+/CD4+T细胞透的增加.

结论:

使用EPI/IMQ@Asphere的TACIE代表了对晚期肝癌的有前途的治疗方法.
化学栓塞和免疫治疗的双重作用,通过可控的药物释放来促进,有效地对抗肝脏瘤并防止转移.
这种策略增强了抗癌免疫力,为肝癌治疗提供了潜在的突破.

关键词:

可生物降解的微球.癌症免疫疗法癌症免疫疗法控制的药物释放控制的药物释放.肝细胞癌 (HCC) 是一种肝细胞癌.通过动脉化学栓塞的超动脉化疗.

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