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在小鼠中选无PFAS与含PFAS灭火剂的潜在生殖和发育影响

Allison M Narizzano¹, Andrew G East¹, Caroline L Procell¹

¹Toxicology Directorate, Defense Centers for Public Health - Aberdeen, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010, USA.

Reproductive toxicology (Elmsford, N.Y.)

|December 27, 2025

概括

这项研究评估了灭火剂,发现无PFAS产品对生殖和发育一般是安全的. 一种不含PFAS的药物在测试剂量时显示出比含PFAS的产品有更高的毒性.

科学领域:

毒理学毒理学毒理学
环境健康环境健康
化学安全化学安全

背景情况:

和多基基物质 (PFAS) 被广泛使用,但引起了健康问题.
灭火剂 (FEAs) 需要严格的毒性测试.
评估既含有PFAS的传统FEA,也评估没有PFAS的新型FEA对于安全性评估至关重要.

研究的目的:

评估六种FEA在小鼠中的生殖和发育毒性.
为了比较一个遗留的含PFAS的FEA与五个不含PFAS的FEA的毒性概况.
为了确定没有PFAS的FEAs是否会在职业相关度下引起不良影响.

主要方法:

在小鼠中进行了重复剂量和生殖/发育毒性研究.
动物通过口腔输液获得高达1000mg/kg-d的FEAs.
暴露包括父母和后代的交配前,怀孕,哺乳期和产后时期.

主要成果:

对于任何FEA,没有观察到生殖功能或怀孕的显著减少.
一些FEA的高剂量,包括无PFAS产品,降低了母,幼和断奶婴的体重.
甲状腺激素和免疫球蛋白干扰是罕见的;在各种产品中观察到一些血液学变化.

结论:

没有PFAS的FEA与单个PFAS暴露的典型生殖或发育影响无关.
一个没有PFAS的FEA表现出比含有PFAS的产品更高的毒性.
结果表明,无PFAS的FEAs可能提供更安全的替代品,尽管产品特定的评估仍然很重要.

关键词:

其他替代品替代品水性薄膜形成泡是一种水性泡.基准剂量的基准剂量发展发展发展发展发展在PFAS中,有很多方法.生殖生殖的繁殖

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