社会经济地位和前列腺特异性抗原检测:基于人口的队列研究,比较有组织和机会性前列腺癌检测
Markus Arvendell1, Ahmad Abbadi2, Lottie Phillips1
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Urology, Södersjukhuset, Stockholm, Sweden.
European urology focus
|December 27, 2025
概括
组织前列腺癌检测 (OPT) 增加了前列腺特异性抗原 (PSA) 检测率. 然而,PSA检测的社会经济差异仍然存在,这表明需要有针对性的战略,以确保公平参与前列腺癌查.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在机会性前列腺特异抗原 (PSA) 检测前列腺癌 (PCa) 中,社会经济差异得到了充分证实.
- 组织前列腺癌检测 (OPT) 计划旨在改善查准入和公平.
研究的目的:
- 评估在斯德哥尔摩县引入OPT是否减少了PSA测试中的社会经济差异.
- 为了比较PSA测试协会与社会经济地位之间的邀请和不符合条件的男性.
主要方法:
- 一项基于登记的队列研究包括被邀请参加OPT的男性 (n=33,754) 和同时不符合条件的对照组 (n=76,535).
- 后勤回归分析了社会经济指标 (教育,收入,民事状况,出生国) 和PSA测试之间的关联.
- Z测试比较了OPT受邀者和不符合条件的队列之间的这些关联.
主要成果:
- OPT增加了整体PSA测试 (39%对13%).
- 高等教育与OPT受邀者 (OR 1.88) 的测试增加有关,但不涉及不符合条件的男性 (OR 1.03).
- 收入差异持续存在,收入较高与两个群体的测试增加有关,特别是不符合条件的群体.
结论:
- 组织前列腺癌检测 (OPT) 提高了整体PSA检测率,但并没有消除社会经济差异.
- 有针对性的策略至关重要,以确保公平参与前列腺癌查计划.
- 进一步的研究应解决影响测试差异的潜在残留混因素.
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