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在HtL1/FBA10上的O-GlcNAc和酸化修饰调节了小麦在开花时的本土化

Pengfang Yang^1,2, Yangyang Liu^1,3, Qi Dong^1,2

¹State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, China.

Nature communications

|December 27, 2025

概括

维纳化通过调节一种果糖1,6-双酸盐阿尔多酶 (FBA) 基因,HtL1/FBA10.0来调节小麦开花时间. 这种糖代谢与表观遗传调节的联系增强了VERNALIZATION 1 (VRN1) 基因转录,改善了冬季小麦的弹性.

科学领域:

植物生物学植物生物学
遗传学是一个遗传学.
农业科学农业科学

背景情况:

小麦的开花时间对产量和适应性至关重要,受本土化和糖代谢的影响.
碳水化合物新陈代谢与小麦的本土化反应之间的分子联系仍然不太清楚.
花期基因的遗传多样性是开发适应气候变化的小麦品种的关键.

研究的目的:

为了确定将碳水化合物代谢与小麦的春季化诱导的开花时间调节联系在一起的基因.
阐明糖代谢影响表观遗传修饰控制开花时间的机制.

主要方法:

全基因组关联研究 (GWAS) 针对小麦核心生殖质收集.
对HtL1/FBA10单元类型的进化分析.
生物化学试验以评估HtL1/FBA10酸化,O-GlcNAcylation和酶活性.
在VERNALIZATION 1 (VRN1) 位点对基因素乙化的分析.

主要成果:

一个果糖1,6-双酸盐阿尔多酶 (FBA) 基因,HtL1/FBA10,被确定为小麦出货时间的关键调节器.
进化分析显示,现代小麦品种中HtL1的晚期开花类型下降.
化改变了HtL1/FBA10的翻译后修饰 (化和O-GlcNAcylation),增强了它的活性,并通过表观遗传变化促进了VRN1的转录.

结论:

在冬季小麦中,HTL1/FBA10充当了葡萄糖代谢和本地化途径之间的分子桥梁.
这些发现揭示了一种涉及糖代谢和开花时间的表观遗传调节的新机制.
这项研究为培育具有优化开花时间的适应气候变化的小麦品种提供了见解.

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