根据光谱效应关系,网络药理学和分子对接技术的基础上,Lonicera macranthoides Hand.-Mazz的抗炎作用
Zhou Wei1, Huang Junfei2, Pan Runsang1
1Department of Orthopedics, Guizhou Provincial People's Hospital, Guiyang, China.
Scientific reports
|December 27, 2025
概括
来自Lonicera macranthoides的单酸C (ILAC) 具有显著的抗炎作用. 这种化合物向多种炎症调解剂,支持传统用途,并表明新药开发的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
背景情况:
- 传统上,Lonicera macranthoides是用于炎症疾病的.
- 识别活性化合物及其机制对于治疗验证至关重要.
研究的目的:
- 调查Lonicera macranthoides提取物及其活性成分异基酸C (ILAC) 的抗炎性质.
- 通过综合计算和实验方法阐明ILAC抗炎活性背后的分子机制.
主要方法:
- 频谱效应关系分析 (HPLC-PLS) 以确定活性化合物.
- 网络药理学预测ILAC的目标.
- 分子对接以评估结合亲和力.
- 在体外使用LPS刺激的RAW 264.7巨细胞进行抗炎试验.
主要成果:
- 朗尼克拉 (Lonicera macranthoides) 提取物S4显示出最高的抗炎活性 (45.53%).
- 鉴定出异基酸C (ILAC) 和基酸是关键活性化合物.
- 网络药理学预测了ILAC的113个目标,确定了10个核心目标.
- 分子对接表明ILAC与CASP3,HIF1A和TLR4.4等核心标具有强烈的结合亲和力.
结论:
- 单酸C (ILAC) 是Lonicera macranthoides中一个关键的抗炎成分.
- ILAC可能通过与炎症中介的多目标相互作用来发挥其作用.
- 这项研究提供了对L. macranthoides传统使用的分子洞察力,并突出了ILAC作为潜在的治疗候选者.
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