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心理健康和MASLD之间的关联通过代谢学通过分子洞察力

Dashuai Yang^1,2, Nan Zhao³, Wei Zhang⁴

¹Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Communications medicine

|December 27, 2025

概括

焦虑和抑郁等心理健康状况是发展代谢功能障碍相关的脂肪性肝病 (MASLD) 的危险因素. 代谢变化,包括肌素和脂质变化,部分解释了这种联系,提供了新的干预目标.

科学领域:

精神病学和内分泌学精神病学和内分泌学
肝病学和代谢疾病

背景情况:

精神健康障碍和与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球重要的健康问题.
心理健康和MASLD病原体之间的相互作用尚未得到充分理解.

研究的目的:

调查心理健康状况与MASLD发病率之间的关联.
探索新陈代谢变化的调解作用在心理健康和MASLD之间的关系.

主要方法:

一项使用英国生物库数据的前性队列研究分析了焦虑,抑郁,躁狂和创伤得分.
使用弹性网规范化和考克斯比例危险模型识别了代谢特征.
调解分析量化了代谢途径对心理健康-MASLD关联的影响.

主要成果:

在心理健康负担和MASLD发病率之间观察到显著的剂量反应关系.
焦虑,抑郁,躁狂和创伤暴露都与MASLD风险增加有关 (HRs从1.13到1.22不等).
肌氨酸,谷氨胺和VLDL-triglyceride%成为关键的代谢媒介,在所有心理领域 (11.2%15.7%) 观察到显著的调解效应.

结论:

临床上显著的心理健康状况被确定为MASLD发展的风险因素.
代谢失调,特别是在代谢和脂质分割方面,部分介导了心理健康和MASLD之间的联系.
这些发现表明,跨学科干预措施的潜在目标是解决肝硬化症中精神体路径.

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