动态轴向拉伸对动脉脉冲波速的影响:物理基础和临床影响
Shaiv Parikh1,2,3, Koen D Reesink4, Bart Spronck4,5
1Center for Research and Innovation in Bioengineering, Universitat Politècnica de València, València, Spain. parikhshaiv12@gmail.com.
Annals of biomedical engineering
|December 27, 2025
概括
该研究表明,上升胸前大动脉 (ATA) 的动态轴延长增加了压力脉冲波速度 (PWV). 这一发现对于准确的临床PWV测量至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 计算力学 计算力学 计算力学
背景情况:
- 传统的压力脉冲波速度 (PWV) 模型假设线性动脉弹性,忽略轴动力学.
- 动脉,特别是上升胸前大动脉 (ATA),表现出非线性,异构性质,并在心脏循环期间经历轴延长.
- 现有的PWV导数不考虑动态轴延长对局部波速的影响.
研究的目的:
- 导出和分析动态轴延长对高弹性上升胸前动脉 (ATA) 中局部PWV的影响.
- 通过结合非线性动脉力学和轴向拉伸来挑战传统的PWV方程.
- 在ATA中为PWV评估提供更准确的生物力学模型.
主要方法:
- 使用Gasser-Ogden-Holzapfel模型分析推导的ATA合规性,将直径变化与压力和轴向拉伸联系起来.
- 生成合成压力-直径曲线,带有不同轴向应变 (0-8%) 叠加于压缩-至-压缩加压.
- 通过直径-压力曲线的斜率和分析导数计算合规性;使用常规波方程与导出合规性确定PWV.
主要成果:
- 导出的合规值与从直径-压力曲线的斜率计算的值非常相匹配.
- 压力脉冲波速度 (PWV) 显示,随着轴向应变的增加,压力脉冲波速度显著增加,即使在恒压条件下.
- 该研究证实了轴动力学对动脉生物力学和波传播的影响.
结论:
- 动态轴延长显著影响上升胸前大动脉 (ATA) 中的局部PWV测量.
- 对于PWV的临床解释,应考虑动脉轴动力学的影响,以提高准确性.
- 这些发现需要对传统的PWV模型进行修订,以包括非线性和异型动脉特性.
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