HUBMet:人类血液代谢物和代谢物-蛋白质关联的综合数据库和分析平台
Xingyue Wang1,2, Xiangyu Qiao1,2, Alberto Zenere1,2
1Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 83, Sweden.
Genome biology
|December 27, 2025
概括
我们开发了HUBMet,一个用于分析血液代谢物及其蛋白质关联的网络服务器,以了解生理学和疾病. 一项COVID-19病例研究强调了其在识别疾病相关代谢特征方面的实用性.
科学领域:
- 生物化学 生化学
- 系统生物学 系统生物学
- 生物信息学是一种生物信息学.
背景情况:
- 人类血液代谢物对于理解生理学和疾病至关重要.
- 在研究代谢物方面存在挑战,原因是它们的不同来源和动态调节.
研究的目的:
- 开发HUBMet,一个开放式访问的网络服务器,用于对血液代谢物及其蛋白质关联的全面分析.
- 提供丰富,定量,组织特异性和代谢物网络分析的工具.
主要方法:
- 开发了HUBMet,整合了3,950种代谢物和129,814种代谢物-蛋白质关联.
- 实施了四个分析模块:过度表示分析 (ORA),代谢物集丰富分析 (MSEA),组织特异性分析 (TSA) 和代谢物-蛋白质网络分析 (MPNet).
主要成果:
- HUBMet为探索代谢物-蛋白相互作用提供了一个强大的平台.
- 一个COVID-19病例研究成功地使用HUBMet.识别了与疾病严重程度相关的代谢特征.
结论:
- HUBMet增强了对人类血液代谢物及其在系统生理学和疾病中的作用的研究.
- 该工具有助于发现COVID-19等疾病的代谢生物标志物.
更多相关视频
07:11Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
Published on: November 10, 2023
3.2K
09:52A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
Published on: January 10, 2025
1.2K
相关概念视频
Protein Networks
4.4K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.4K
Proteomics
9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.2K
