PGC-1α:是线粒体生物发生和细胞分化在代谢和再生组织中的关键调节器
Lijuan Cao1, Yanan Li1, Artem Smirnov2,3
1The Fourth Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Cell & bioscience
|December 28, 2025
概括
过氧体增殖器激活的受体 γ 协同激活器 1α (PGC-1α) 对于细胞分化和线粒体生物生成至关重要. 了解PGC-1α的作用为开发和再生医学提供了洞察力.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
背景情况:
- 过氧体增殖器激活受体 γ 协同激活器 1α (PGC-1α) 是线粒体生物发生和功能的关键调节者.
- 在整个组织中,PGC-1α表现出多种异型,影响线粒体功能,氧化应激和ER恒温.
- PGC-1α最初在棕色脂肪组织中被发现,调节基因表达以应对寒冷.
研究的目的:
- 审查PGC-1α在细胞分化中的关键作用.
- 探索PGC-1α对基因表达网络的影响,这些基因表达网络控制着线粒体生物发生.
- 要突出PGC-1α对各种细胞类型细胞命运决定的影响.
主要方法:
- 文献综述侧重于PGC-1α在细胞分化中的功能.
- 分析PGC-1α在调节基因表达中的作用.
- 检查PGC-1α对脂肪细胞,骨肌细胞和骨髓衍生细胞的影响.
主要成果:
- PGC-1α显著调节了线粒体生物生成所必需的基因表达网络.
- PGC-1α在脂肪细胞,骨肌细胞和骨髓衍生细胞的分化中起着至关重要的作用.
- 特定于组织的PGC-1α异型体有助于产生多种生物效应.
结论:
- 了解PGC-1α在细胞分化中的功能对于发育生物学和组织形成至关重要.
- PGC-1α代表了再生医学和疾病治疗的潜在治疗标.
- 本综述提供了关于PGC-1α在组织和生物体发育中的意义的综合视角.
相关概念视频
02:23Master Transcription Regulators
7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
01:19Regulation of Metabolism
11.3K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.3K
01:37Mitochondria
19.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.4K
01:39Mitochondrial Precursor Proteins
3.5K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70 chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
Most of the mitochondrial...
3.5K
02:38Mitogens and the Cell Cycle
7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
01:58Cell Specific Gene Expression
16.2K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.2K