性酸酶作为尾炎炎炎症反应得分的辅助剂
A M Abidah Tanweer1, C L Rahul Raj2, E E Evelyn3
1Department of General Surgery, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai Bengaluru, Chennai, Tamil Nadu, India. abidah6297@gmail.com.
The Medical journal of Malaysia
|December 28, 2025
概括
将性酸酶 (ALP) 添加到尾炎炎炎症反应 (AIR) 评分,显著提高了尾炎诊断的准确性. 这种增强有助于临床决策,并减少尾炎不必要的手术.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 手术病理学手术病理学
- 生物标志物研究 生物标志物研究
背景情况:
- 尾炎是一种常见的手术紧急情况,需要准确的诊断.
- 目前的诊断方法,包括尾炎炎炎症反应 (AIR) 评分,有局限性,特别是在复杂的情况下.
- 性酸酶 (ALP) 是一种炎症标志物,可以提高诊断精度.
研究的目的:
- 评估将酸酸酶 (ALP) 水平纳入尾炎炎炎症反应 (AIR) 评分的影响.
- 在疑似尾炎的患者中评估增强的AIR得分的诊断准确性.
主要方法:
- 一项观察性研究涉及112名疑似尾炎的患者.
- 患者使用AIR得分进行评估,包括或不包括ALP水平.
- 统计分析包括灵敏度,特异性,NPV,PPV和ROC曲线分析.
主要成果:
- AIR评分显示,最初的灵敏度为80%,特异性为75%.
- 整合ALP使灵敏度提高到92%和特异性提高到85%.
- 曲线下的面积 (AUC) 从ALP的0.78提高到0.92,ALP的最佳切线为90IU/L.
结论:
- 将ALP整合到AIR得分中可以显著提高尾炎的诊断准确性.
- ALP显示出作为改善尾炎诊断的有价值生物标志物的潜力.
- 这种增强可以导致更好的临床决策,减少手术和改善患者结果.
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