[治疗性低温对中风后睡眠障碍的影响]
D V Torshin1, O A Shevelev1,2, A I Fedin3
1Federal Research and Clinical Center of Resuscitation and Rehabilitation, Moscow, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|December 28, 2025
概括
治疗性低温症,特别是脑低温症 (CCH),改善了缺血性中风患者的睡眠质量. 降低大脑温度提高了睡眠效率,降低了清醒度,特别是在脊髓基底系统中风患者中.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 治疗性低温症 治疗性低温症
背景情况:
- 缺血性中风 (IS) 显著影响患者的康复,经常影响睡眠质量.
- 了解在早期康复期间改善睡眠的因素对于神经康复至关重要.
研究的目的:
- 调查治疗性低温对缺血性中风早期恢复阶段患者睡眠质量的影响.
- 为了确定脑低温 (CCH) 是否影响IS患者的睡眠参数.
主要方法:
- 一项涉及32名IS患者的研究,分为接受CCH的测试组 (n=22) 和接受标准治疗的对照组 (n=10).
- CCH涉及每天10次90分钟的会议,通过非侵入性放射热度计监测大脑皮层温度.
- 睡眠质量通过测量总睡眠时间,睡眠效率指数,N2阶段睡眠时间和睡眠期间醒来的时间来评估.
主要成果:
- 与对照组相比,脑低温在试验组显著降低了大脑皮质温度 (p<0.015),特别是在脊椎基底系统IS患者中 (p<0.001).
- CCH组表现出显著的改善:增加了总睡眠 (327分 vs 263分),更高的睡眠效率 (62.3% vs 51%),更多的N2阶段睡眠 (29.0% vs 25.6%),并减少了唤醒时间 (34.5% vs 40%) (p<0.05).
- 睡眠质量的改善在IS患者中最显著,其中包括脊椎基底系统;对照组没有观察到任何显著的变化.
结论:
- 这些发现支持大脑温度降低和睡眠过程改善之间的联系.
- 通过CCH,治疗性低温提供了一种潜在的策略,可以在缺血性中风的早期恢复期提高睡眠质量.
- 准大脑温度可能是优化中风幸存者的神经恢复和睡眠的关键因素.
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