Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 7, 2026

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

6.0K

为进行翻译性研究而开发一种临床前重度压性SCI小鼠模型的协议.

Sissi Dolci1, Marzia Di Chio1, Giuseppe Busetto2

  • 1Laboratory of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy.

STAR protocols
|December 28, 2025
PubMed
概括

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effect of Sterilization Methods on the Physicochemical Properties of Silk Fibroin Hydrogels.

Polymers·2026
Same author

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.

Cell·2026
Same author

Corneal regenerative contribution of endogenous and grafted limbal-corneal cells in a mouse model of simple limbal-corneal epithelial transplantation.

Stem cells translational medicine·2026
Same author

Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair.

Immunity·2026
Same author

Targeting PGC-1α axis rescues aberrant development from thyroid hormone defect in brain organoids.

Pharmacological research·2025
Same author

Continuous interstitial glucose monitoring in diabetic and non-diabetic critically ill patients is simple and accurate: comparison with venous, arterial and capillary glucose measurements.

Acta diabetologica·2025

这项研究详细介绍了在小鼠中诱导严重脊髓损伤 (SCI) 的方案. 这种可复制的模型有助于对神经损伤的新疗法进行临床前测试.

科学领域:

  • 神经科学是一个神经科学.
  • 再生医学是一种再生医学.
  • 手术技巧 手术技巧

背景情况:

  • 完全脊髓损伤 (SCI) 会导致不可逆转的神经损伤.
  • 目前对SCI的治疗方法有限,因为神经修复失败.

研究的目的:

  • 在小鼠的胸部T11水平上诱导严重的性压缩性SCI的详细方案.
  • 建立一个可重复的临床前模型来测试SCI治疗方法.

主要方法:

  • 在T11胸部水平进行拉米内切除术.
  • 使用NYU-MASCIS II冲击器进行SCI诱导.
  • 通过功能和组织学分析验证损伤.

主要成果:

  • 成功诱导严重的压性SCI.
  • 展示人类二次伤害的关键方面.
  • 为临床前研究建立一个可靠的模型.

结论:

  • 描述的协议为SCI治疗的临床前测试提供了有价值的工具.
  • 该模型有效地复制了人类二次损伤的关键特征,促进了对有效治疗方法的研究.
关键词:
健康科学 卫生科学 卫生科学模型生物模型生物神经科学是一个神经科学.

更多相关视频

Author Spotlight: Insight Into Innovations in Spinal Cord Injury Research
06:31

Author Spotlight: Insight Into Innovations in Spinal Cord Injury Research

Published on: January 19, 2024

2.7K
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
07:59

A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice

Published on: June 18, 2017

11.7K

相关实验视频

Last Updated: Jan 7, 2026

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

6.0K
Author Spotlight: Insight Into Innovations in Spinal Cord Injury Research
06:31

Author Spotlight: Insight Into Innovations in Spinal Cord Injury Research

Published on: January 19, 2024

2.7K
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
07:59

A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice

Published on: June 18, 2017

11.7K