药用异环设计中的可持续声化学:进步和抗癌影响
Priteeparna Das1, Vijayakumar Hemamalini2, N Pawar1
1Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, Samantapuri, Bhubaneswar, Odisha 751013, India.
Bioorganic chemistry
|December 28, 2025
概括
超声波辅助合成提供了一种可持续的方法,用于制造抗癌异环化合物. 这种方法加快了反应,提高了产量,减少了药物化学中的能源和危险溶剂使用.
科学领域:
- 药用化学 医学化学
- 有机合成 有机合成
- 绿色化学 绿色化学
背景情况:
- 超声波辅助合成是可持续和高效的合成策略的强大工具.
- 含有,硫和氧的异环环在药物化学中是重要的支架,其中一些表现出抗癌活性.
- 最近的注意力集中在利用超声波能量来合成这些有价值的异环化合物.
研究的目的:
- 综合总结了近期超声波介导的合成方法对异环合成的进展.
- 突出声化学方法的好处,包括加速反应速度,提高产量,降低能源消耗,并尽量减少使用危险的溶剂和催化剂.
- 从2021年到2025年,审查使用声化学方法合成的异环体的抗癌特性.
主要方法:
- 在2021年至2025年期间发表的对异环合成的声化学方法的综述.
- 专注于超声波介导的合成方法,包括多元组分反应,无效和循环.
- 在实验室中对合成的异环化合物对各种癌症细胞系的抗癌活性进行分析.
主要成果:
- 与传统方法相比,超声中介合成加速了反应速率并增加了产量.
- 声化学方法可以在环境或低能量的条件下实现复杂的转换.
- 在试验室中,合成的异环环体对几种癌细胞系表现出显著的细胞毒性.
结论:
- 超声波辅助合成为有价值的异环基架提供了可持续和高效的途径.
- 这种方法比传统技术具有显著的优势,与绿色化学原则保持一致.
- 合成的异环体显示出有前途的抗癌潜力,需要进一步研究.
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