在妊娠前后预测心血管疾病:新兴工具和早期检测方法
Chiara Alfaré1, Emma M Giesen2, Evelyn A Huhn2
1Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Medicine and Surgery, University of Parma, Italy.
Journal of reproductive immunology
|December 28, 2025
概括
孕前史增加了长期心血管疾病 (CVD) 的风险. 本综述探讨了像GLS和USCOM这样的生物标志物和成像,用于在孕前后的女性中早期发现心血管疾病和风险分层.
科学领域:
- 心血管医学 心血管医学
- 产科 产科 产科 产科 产科
- 生物标志物 生物标志物
背景情况:
- 孕前 (PE) 是长期心血管疾病 (CVD) 的重要危险因素.
- 缺少PE后心血管随访的指导方针.
- 由于心血管疾病发病率的高负担,在有PE病史的妇女中早期发现心血管疾病至关重要.
研究的目的:
- 审查有关预测工具和策略的现有证据,以预测心脏病预测和早期诊断PE病史的女性.
- 总结循环生物标志物和先进成像技术在PE后心血管风险评估中的作用.
主要方法:
- 在PE后对CVD预测和诊断研究的文献综述.
- 对循环生物标志物的分析 (例如,sFlt1,sEng,IL-6,Activin A).
- 图像技术的评估 (例如,全球纵向菌株 - GLS,超声波心脏输出监测器 - USCOM).
主要成果:
- 抗血管原标记 (sFlt1,sEng) 和sFlt1/PlGF比率的升高与亚临床心肌功能障碍和产后高血压相关.
- 增加的IL-6表明持续的炎症,升高的活性蛋白A表明怀孕高血压障碍 (HDP) 后的心脏压力.
- GLS是早期心肌功能障碍的敏感参数,USCOM显示了HDP的血液动力学监测和治疗量身定制的潜力.
结论:
- 循环生物标志物,高级心声回声学 (GLS) 和非侵入性血液动力学监测 (USCOM) 可以完善PE后的心血管风险分层.
- 这些工具支持针对女性的有针对性的监测和预防策略的潜力,这些妇女长期处于心血管疾病风险之中.
- 需要进一步的研究来验证这些工具,并制定最终的管理准则.
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