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基于性和LSPR效应的cuproptosis敏感剂,用于逆转瘤微环境,用于黑色素瘤治疗

Lidan Liu¹, Mei Li², Panpan Huo³

¹State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Department of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200233, China.

|December 28, 2025

概括

这项研究引入了MgO/Cu@C纳米反应器,可以逆转瘤酸度并增强癌症疗法cuproptosis. 这种方法对黑色素瘤治疗和伤口愈合有希望.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

杯性瘤是一种有前途的癌症治疗方法,但其疗效受到酸性瘤微环境 (TME) 和高谷氨 (GSH) 水平的限制.
开发克服TME限制的策略对于增强基于cuproptosis的癌症治疗至关重要.

研究的目的:

构建一种新的纳米反应器 (MgO/Cu@C),利用性和局部表面等离子体共振 (LSPR) 来使黑色素瘤中质亡敏感.
研究性和LSPR增强GSH耗尽和增强cuproptosis的机制.

主要方法:

制造具有性和近红外 (NIR) 光热性能的MgO/Cu@C纳米反应器.
对黑色素瘤细胞的MgO/Cu@C+NIR治疗的评估,包括TME逆转和GSH耗尽.
RNA测序转录组分析以阐明cuproptosis诱导机制.

主要成果:

MgO/Cu@C纳米反应器成功逆转了酸性TME并增强了GSH耗尽.
MgO/Cu@C和NIR光的组合有效地使黑色素瘤细胞对cuproptosis敏感.
鉴定出的机制包括铜过载,代谢途径抑制,高血压素过活化和改变的信号通路.

结论:

MgO/Cu@C + NIR治疗为黑色素瘤治疗和伤口愈合提供了一种双重方法,通过诱导质亡和抑制细菌感染.
性和LSPR协同增强GSH耗尽,并通过逆转酸性TME来提高cuproptosis的敏感性.
这项研究为黑色素瘤治疗提供了一个新的视角,利用性增强的性.

关键词:

性是一种性.这种疾病叫做cuproptosis.这是LSPR效应.黑色素瘤是一种黑色素瘤.瘤微环境是一个微环境.

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