基本微量元素及其对免疫反应及其对疟疾感染疾病严重性的影响:系统性审查
Haleh Hanifian1, Mehdi Nateghpour1, Maziar Naderi2
1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Parasite immunology
|December 28, 2025
概括
疟疾感染显著改变了必需的微量元素,如铁,和,影响免疫功能和疾病的严重程度. 解决这些缺陷可能会改善疟疾治疗结果.
科学领域:
- * 传染病和免疫学
- * 营养生物化学 * 营养生物化学
- * 全球卫生健康
背景情况:
- * 疟疾对全球健康造成重大负担,影响宿主免疫力和营养状况.
- * 微量元素 (铁,,铜,) 对于免疫功能和病原体控制至关重要.
- * 关于疟疾期间的微量元素变化及其临床影响,存在不一致的报道.
研究的目的:
- *系统地审查有关疟疾血清/血微量元素度的证据.
- * 评估微量元素,免疫反应和疾病结果之间的关系.
- * 评估微量元素在疟疾诊断和预后中的作用.
主要方法:
- *从2010年到2025年进行系统的文献搜索 (PubMed,科学网,Scopus,谷歌学者).
- *使用关键评估技能计划 (CASP) 工具进行质量评估.
- *遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- * 疟疾始终与血清铁,和的减少有关.
- *铜含量呈现变化趋势,在急性感染期间经常升高,表明炎症.
- *这些变化与失调的细胞因子产生 (TNF-α,IL-10),较高的寄生素血量和更糟糕的结果相关.
结论:
- * 疟疾会破坏微量元素恒温,导致免疫功能障碍和氧化应激.
- * 减少铁,,和改变的铜加剧了疟疾的严重程度.
- * 与抗疟疾治疗一起的向微量营养素干预可以改善宿主免疫力和结果.
相关概念视频
The Periodic Table and Organismal Elements
199.2K
Overview
199.2K
The Periodic Table and Organismal Elements
22.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
22.1K
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Fungal Phylum Microsporidia
374
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
374


