向USP28抑制清细胞细胞癌的生长
Ying Ren1, Yunfang Yang2, Xiaodan Zhu3
1Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.
Cellular signalling
|December 28, 2025
概括
研究人员发现,USP28在清细胞细胞癌 (ccRCC) 中稳定了c-Myc蛋白. 抑制USP28降低c-Myc,减缓ccRCC细胞生长,并缩小瘤,为这种癌提供了一个新的治疗标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 清细胞细胞癌 (ccRCC) 是最常见的癌,缺乏有效的向治疗.
- 在ccRCC中,c-Myc的过度表达是常见的,但控制其稳定的机制尚不清楚.
- 了解c-Myc调节对于开发新型ccRCC疗法至关重要.
研究的目的:
- 在ccRCC中确定c-Myc蛋白稳定性的关键调节者.
- 研究针对ccRCC中的c-Myc稳定通路的治疗潜力.
主要方法:
- 在ccRCC细胞中研究了USP28和c-Myc之间的相互作用.
- 评估了USP28在c-Myc二维基因化和蛋白质体降解中的作用.
- 在体外和体内cccRCC模型中利用了USP28的遗传和药理抑制.
- 与USP28抑制的敏感性相关的c-Myc表达水平.
主要成果:
- USP28通过去除K48连接的链,防止其降解,使c-Myc二化.
- 抑制USP28可显著降低c-Myc水平,损害ccRCC细胞增殖,并抑制瘤生长.
- 具有高c-Myc表达的ccRCC瘤对USP28抑制更为敏感.
结论:
- USP28是ccRCC中c-Myc蛋白稳定性的关键调节者.
- 针对USP28代表了对ccRCC的有前途的治疗策略,特别是在高c-Myc.
- 这项研究强调了USP28-c-Myc轴作为癌的潜在治疗标.
相关概念视频
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Inhibition of Cdk Activity
5.5K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
Abnormal Proliferation
5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K


