感染性内心炎的风险在接受Enterococcus faecalis血流感染主动治疗的瘤血液病患者:一项回顾性多中心研究
Miguel Ángel Consuegra Pérez1, Sara Grillo2, Alexander Rombauts2
1Infectious Diseases Division, Internal Medicine Department. Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08025, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
International journal of antimicrobial agents
|December 28, 2025
概括
对于患有Enterococcus faecalis血流感染 (EF-BSI) 和癌症的患者,感染性内心炎 (IE) 查可能不需要. 建议对这些高风险患者进行基于临床风险因素的个性化评估.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 心脏病学 心脏病学
背景情况:
- 菌血流感染 (EF-BSI) 是感染性内心炎 (IE) 的重要原因之一.
- 目前的指导方针建议在EF-BSI患者中对IE进行系统的心声学查.
- 这种查在患有活跃瘤性血性恶性瘤的患者中的有用性需要进一步研究.
研究的目的:
- 为了确定感染性内心炎 (IE) 的风险,在患有Enterococcus faecalis血流感染 (EF-BSI) 和活跃的瘤血液恶性瘤的患者中.
- 在这个特定的患者群体中评估系统性心声学查的产量.
主要方法:
- 在西班牙巴塞罗那的三个癌症中心进行了回顾性多中心队列研究 (2014年1月 - 2023年12月).
- 包括连续患有EF-BSI和活跃的血性恶性瘤的成年患者.
- 主要结局:确定的IE诊断 (欧洲心脏病学会标准);次要结局:30天死亡率,6个月复发,累积死亡率.
主要成果:
- 包括148名患者 (平均年龄64.5岁,53%男性);54%患有血液性恶性瘤,46%患有固体瘤.
- 只有15%的患者接受了心声回声,显示了1% (2患者) 的确定的IE率.
- 30天死亡率为29%,6个月累积死亡率为55%;7%的病例复发,没有新的IE诊断.
结论:
- 对于患有Enterococcus faecalis血流感染 (EF-BSI) 和活跃的血性恶性瘤的患者,可能不需要对系统性感染性内心炎 (IE) 进行查.
- 基于临床风险因素的个性化IE查建议对这一群体进行.
- 进一步的研究可能会完善EF-BSI癌症患者IE风险分层.
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