增强智能用于乳腺癌多式虚拟活检,使用生成人工智能.
Aurora Rofena1, Claudia Lucia Piccolo2, Bruno Beomonte Zobel3
1Unit of Artificial Intelligence and Computer Systems, University Campus Bio-Medico of Roma, Rome, Italy.
Journal of biomedical informatics
|December 28, 2025
概括
这项研究引入了一种生成性AI方法,用于创建合成对比增强光谱乳房学 (CESM) 图像,在缺少真实CESM数据时改进非侵入性乳腺癌虚拟活检. 这种人工智能增强的方法提供了比仅使用全场数字猛乳镜 (FFDM) 更好的病变分类.
科学领域:
- 医疗成像医学成像
- 医疗保健中的人工智能
- 在瘤学瘤学.
背景情况:
- 乳腺癌的诊断依赖于成像技术,如全场数字乳房镜像 (FFDM) 和对比增强光谱乳房镜像 (CESM).
- 缺少CESM数据可能会破坏诊断工作流程并影响分类准确性.
- 虚拟活检提供了一种非侵入性方法来分类乳腺病变.
研究的目的:
- 为乳腺癌虚拟活检开发一种多式,多视图的深度学习方法.
- 整合FFDM和CESM数据以改善损伤分类.
- 为了解决缺失的CESM数据,使用生成AI进行图像合成.
主要方法:
- 一个CycleGAN模型从FFDM输入中合成了缺失的CESM图像.
- 三个卷积神经网络 (ResNet18,ResNet50,VGG16) 被用来进行分类.
- 一个两阶段的晚期融合策略结合了视图特异性和模式特异性概率,并使用马修斯相关系数 (MCC) 进行加权.
主要成果:
- 生成型人工智能实现了CESM图像的高保真合成 (PSNR> 24dB,SSIM> 0.8).
- 多模式方法 (FFDM + CESM) 的表现优于单模式的FFDM单一分类.
- 即使使用完全合成的CESM图像,多式联络方法也比单纯的FFDM提高了性能.
结论:
- 生成型人工智能有效地合成CESM图像,克服乳腺癌诊断中的数据缺口.
- 整合合成CESM图像可以提高基于FFDM的虚拟活检性能.
- 这种非侵入性方法支持临床决策,并提供了有价值的数据集 (CESM@UCBM).
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