单个供体血小板在含容器染色的血小板添加剂溶液中的异常色变色:一种罕见的观察
Suvetha Rajendran1, Harsha Unni1, Mohandoss Murugesan1
1Transfusion Medicine, Malabar Cancer Centre, Postgraduate Institute of Oncology Sciences and Research, Thalassery, India.
Journal of clinical apheresis
|December 28, 2025
概括
存储在血小板添加剂溶液 (PAS) 中的异常黄斑外观与捐赠者的高白血症有关. 这一案例突出了潜在的捐赠者衍生色素转移,表明需要重新评估血液成分视觉检查标准.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 血液成分加工 血液成分加工
背景情况:
- 血小板添加剂溶液 (PAS) 用于延长血小板缩物的储存时间.
- 视觉检查是评估血液成分质量的主要方法.
- 血液制品中性变色通常与血液溶解或肝脏功能障碍有关.
研究的目的:
- 报告一个非同寻常的黄色变的病例在一个非血小板 (AP) 单位.
- 调查变色的原因及其对血小板质量的影响.
- 讨论对血液储存实践的影响.
主要方法:
- 一个AP单位的案例报告,出现了黄色变色和袋子染色.
- 无菌培养和初始血小板形态评估.
- 捐赠者评估,包括胆红素水平.
- 在存储过程中进行血小板功能测试.
主要成果:
- 该AP单元显示明显的黄斑变色和袋子染色,尽管无菌培养和保存初始形态.
- 捐赠者评估显示轻度非结合性高 bilirubinemia.
- 存储5天后,血小板功能降低了.
- 捐赠者衍生的颜料被认为是变色的来源.
结论:
- 尽管很少见,但PAS悬浮血小板中的性外观可能表明与捐赠者相关的色素转移.
- 这一案例表明,目前的视觉检查方法可能无法检测出所有质量问题.
- 对血液成分的接受标准进行重新评估是有必要的.
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