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在口腔状细胞癌中,TP53基因型依赖的细胞对DVDMS-声动疗法的反应

Guo-Gang Dong¹, Pin-Xiu Pan², Feng-Ting Zhang²

¹Department of Anatomy, School of Basic Medical Sciences, Harbin Medical University, Harbin, China; Department of Radiology, Jinling Hospital Affiliated to the Medical School of Nanjing University, Nanjing, China.

Ultrasound in medicine & biology

|December 28, 2025

概括

声动力疗法 (SDT) 配合色氨酸 (DVDMS) 有效抑制了口腔状细胞癌 (OSCC) 的生长,对野生型TP53细胞的影响更大. 该疗法诱导了亡和调节的自,突出了p53的作用.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
分子生物学分子生物学

背景情况:

口腔状细胞癌 (OSCC) 在治疗中存在挑战,需要新的治疗策略.
声动疗 (SDT) 是一种非侵入性的癌症治疗方法.
TP53基因型在治疗反应中的作用仍然是积极研究的领域.

研究的目的:

为了评估SDT的有效性,在OSCC细胞中使用sinoporphyrin (DVDMS).
阐明DVDMS介导SDT的潜在机制,重点关注TP53基因型变异.
评估SDT对细胞增殖,细胞亡,自和反应性氧物种 (ROS) 生成的影响.

主要方法:

使用了两个具有明显TP53基因型的OSCC细胞系 (SAS和HSC-3).
细胞毒性,DVDMS吸收,ROS水平,细胞亡和自被测量.
分析了蛋白质表达 (p53,Bax,Bcl-2,LC3B) 和p53抑制.

主要成果:

通过DVDMS介导的SDT显著抑制了两种细胞系的增殖.
与突变TP53 (HSC-3) 细胞相比,SDT在野生型TP53 (SAS) 细胞中诱导了更高的ROS水平和线粒体亡.
通过DVDMS介导的SDT在细胞系之间不同调节了自,并参与了SAS细胞中的p53转位.

结论:

通过DVDMS介导的SDT在具有野生型TP53.3的OSCC细胞中显示出更大的有效性.
该疗法诱导线粒体亡并调节自,p53发挥关键的调节作用.
这些发现支持基于DVDMS的SDT在OSCC治疗中的潜力,特别是在野生型TP53.3患者中.

关键词:

在HSC-3细胞中.口腔状细胞癌的癌症.在SAS单元中,设置SAS单元锡诺波菲林的.声动力学疗法声动力学疗法在 p53 里,p53 是一个 p53 的类型.

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