扩大周血管空间和可修改的血管风险因素:英国生物银行队列的横截面和纵向分析
Shizuka Hayashi1, Jiyang Jiang1, Yang Song2
1Centre for Healthy Brain Ageing (CHeBA) (SH, JJ, MP, PSS, WW), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, Australia.
概括
高血压和吸烟等血管风险因素与老年人周血管空间 (PVS) 的增加有关. 这些发现强调PVS是血管大脑健康和神经退行风险的关键指标.
科学领域:
- 神经成像和神经学 神经学
- 血管生物学和衰老问题
- 遗传学和大脑健康
背景情况:
- 周血管空间 (PVS) 对于大脑的废物清理至关重要.
- 扩大的PVS与衰老和脑血管疾病有关.
- 了解PVS的风险因素对于老年人大脑健康至关重要.
研究的目的:
- 调查血管风险因素,APOE基因型和PVS之间的关联.
- 检查老年人PVS的性别和区域特定模式.
- 探索横截面和纵向关系.
主要方法:
- 利用英国生物库数据从38,121名参与者进行横截面分析和4,225人进行纵向分析.
- 采用深度学习模型从脑MRI中自动量化基底 (BG) 和半圆中心 (CSO) 的PVS.
- 评估了血管风险因素,包括高血压,高胆固醇,肥胖,糖尿病,吸烟和饮酒,根据年龄,性别,扫描仪和APOE-ɛ4状态进行调整.
主要成果:
- 在截面上,高血压,高胆固醇血症,肥胖和吸烟与增加的BG-PVS有关.
- APOE-ɛ4载体和高血压与CSO-PVS的增加有关.
- 酒精消费显示了与BG-PVS的性别特定关联;纵向关联是有限的.
结论:
- 周血管空间 (PVS) 作为血管大脑健康的有意义指标.
- 在老年人群中,PVS可能有助于早期识别神经退行性风险.
- 研究结果强调了管理血管风险因素对大脑健康的重要性.
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