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周围表观基因组预测白质体积与发育阶段相关:一个ECHO研究

Taena Hanson¹, Sophie Spencer¹, Samantha A Harker¹

¹School of Life Sciences and Psychology, Arizona State University, Tempe, AZ, 85287, USA.

Molecular neurobiology

|December 28, 2025

概括

唾液中的外周DNA甲基化 (DNAm) 追踪了儿童的白质量 (WMV),为早期疾病检测提供了潜在的潜力. 这些表观遗传标记对于理解神经发育轨迹至关重要.

科学领域:

神经科学是一个神经科学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
发展生物学发展生物学

背景情况:

白质 (WM) 发育对于神经连接至关重要,其干扰与神经发育障碍有关.
表观遗传机制,特别是DNA甲基化 (DNAm),越来越多地被认为是它们在调节WM结构中的作用.
关于儿童群体中DNAm和WM发育的研究有限.

研究的目的:

调查WM相关基因的外围DNAm与儿童的WM体积 (WMV) 之间的关联.
探索DNAm和WMV之间的年龄相关关系.
评估唾液DNAm与大脑组织DNAm之间的相关性.

主要方法:

利用了环境影响儿童健康结果 (ECHO) 研究的数据.
使用Infinium MethylationEPIC阵列从205名儿童 (2个月15.5岁) 获得了唾液DNAm资料.
使用T1加权MRI量化WMV并进行向表观基因组分析.

主要成果:

在352个基因中确定了1867个CpG位点,显著预测了WMV (FDR q < 0.05).
发现了 11,611 个 CpG 位点与年龄相关联,最明显的是在幼儿时期.
在唾液DNAm和脑组织DNAm之间显示出强烈的相关性 (r = 0.915).

结论:

唾液中的外周DNAm标记可以作为神经发育轨迹的生物标记.
基于唾液的DNAm是儿科神经成像研究的宝贵工具.
发育时间对于理解DNAm-WMV关联至关重要,这对早期发现WM障碍有重要意义.

关键词:

通过DNA甲基化.发展发展发展发展发展表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.神经成像是一种神经成像.白质是白质的组成部分.

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