治疗骨质疏松症的益生菌和共生菌补充剂:随机试验的元分析
Zhiyuan Gong1, Qi Hu2, Zahra Sabagh2
1Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No. N1, Shangcheng Avenue, Yiwu, 322000, Zhejiang, China.
Journal of health, population, and nutrition
|December 28, 2025
概括
益生菌和协生菌补充剂通过降低甲状腺类激素 (PTH) 和增加腰椎骨矿物质密度 (BMD) 来改善骨健康有希望. 然而,对其他骨标记物的影响仍然没有确定性.
科学领域:
- 营养科学 营养科学
- 骨的新陈代谢 骨的新陈代谢
- 微生物组研究 微生物组研究
背景情况:
- 益生菌和共生菌补充剂正在被探索,因为它们有可能增强骨健康标志物.
- 现有的关于它们有效性的证据是不一致的,需要进一步调查.
- 骨质疏松症仍然是一个重大的公共卫生问题,推动了对新型治疗策略的研究.
研究的目的:
- 系统地评估益生菌或共生菌补充剂对骨质疏松症的影响.
- 通过元分析综合现有研究的发现.
- 提供基于证据的洞察力,了解益生菌/共生菌在治疗骨质疏松症中的作用.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了全面的系统文献搜索,截至2025年6月.
- 十个相关研究被纳入了元分析.
- 数据使用随机效应模型进行聚合,以计算标准化平均差异 (SMD) 和95%信心区间 (CI).
主要成果:
- 益生菌/共生菌补充剂显著降低了副甲状腺激素 (PTH) 水平 (SMD = -1.19; P=0.012).
- 腰椎骨矿物质密度 (BMD) 显著增加 (SMD = 0.86;P=0.047).
- 没有观察到对部总骨质量,C终端端 (CTX),骨质素,性酸酶 (ALP) 或骨质保护蛋白的显著影响.
结论:
- 益生菌/共生菌补充剂对PTH水平和腰椎BMD有有益影响.
- 目前的证据不支持对其他关键骨健康指标的有利影响.
- 需要进一步的研究来阐明机制,并优化益生菌/共生菌对骨健康的使用.
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