辅酶Q10补充剂增加了血液度,但对运动表现产生了有限和不一致的影响:系统性审查和元分析
Hengzhi Deng1, Tianyu Song1, Mingyue Yin2
1Faculty of Sports and Exercise Science, University Malaya, Kuala Lumpur, Malaysia.
The British journal of nutrition
|December 28, 2025
概括
辅酶Q10 (CoQ10) 补充可靠地增加血液水平,但在健康成年人中提供最小的,不一致的运动性能益处. 需要进一步的研究来澄清其人体生长潜力.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 运动科学 运动科学 运动科学
背景情况:
- 共酶Q10 (CoQ10) 在线粒体能量生产和抗氧化剂防御中发挥作用.
- 它作为人体生长辅助剂的潜力在生物学上是合理的,但由不一致的试验结果支持.
研究的目的:
- 系统地审查对健康成年人CoQ10对运动表现,疲劳和血液CoQ10水平的影响的随机对照试验.
- 综合有关CoQ10人体营养潜力的证据,并评估研究结果的确定性.
主要方法:
- 来自6个数据库的24项随机试验的系统审查和元分析 (至2025年11月).
- 在健康成年人中,研究比较了辅酶Q10补充剂与安慰剂.
- 使用RoB2评估偏差风险,使用GRADE判断证据的确定性.
主要成果:
- 辅酶Q10补充剂持续增加了循环中的辅酶Q10水平.
- 性能益处很小且不一致,慢性使用显示轻微的益处,在异常因素排除后变得不稳定.
- 在慢性使用下,有氧耐力显示出边缘性益处,而无氧和强度性能显示出最小的变化.
- 减少主观疲劳的证据是暗示性的,并且在异常值被排除后更加一致.
- 训练有素个体的好处是不稳定的,只有在异常排除后才变得一致.
结论:
- CoQ10可靠地提高循环水平,但提供适度和上下文依赖的运动性能好处,主要是在慢性补充剂下.
- 由于异质性和偏见风险,证据的确定性低至非常低.
- 需要进行精心控制的试验,以标准化配方,剂量,持续时间,并研究性别特异性和耐力相关的反应.
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