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血清抗核抗体与早产卵巢衰竭之间的关联:一个元分析

Tejunzhang Pi¹, Zuxian Hu², Lei Luo³

¹Department of Hematology, Guihang 300 Hospital Affiliated to Zunyi Medical University, Guiyang, 550009, Guizhou Province, China.

Journal of ovarian research

|December 28, 2025

概括

抗核抗体 (ANA) 阳性与原发性卵巢缺陷 (POI) 的更高风险有关. 常规的ANA检测可能有助于早期查,特别是在35岁以下或FSH水平高的女性中.

科学领域:

生殖内分泌学生殖内分泌学
免疫学免疫学免疫学
自免疫性疾病自免疫性疾病

背景情况:

自身免疫功能障碍是原发性卵巢缺陷 (POI) 的已知原因之一.
抗核抗体 (ANA) 用于检测自身免疫活性,但它们与POI的关联不一致.
本元分析研究了ANA阳性和POI之间的相关性,以评估ANA作为血清学标记物的潜力.

研究的目的:

为了澄清ANA阳性和POI之间的关联.
评估ANA作为POI中自身免疫参与的潜在血清学标志物.

主要方法:

在多个数据库 (PubMed,EMBASE等) 中进行系统搜索. 在2024年8月之前.
包括与POI患者和对照者的ANA阳性相比较的病例控制研究.
随机效应模型用于计算聚合赔率比率 (ORs) 和95%置信区间 (CI).
评估异质性 (I2统计) 和出版偏差 (贝格测试).

主要成果:

ANA阳性与POI显著相关 (OR2.57,95%CI:1.62-4.08).这种阳性与POI显著相关.
在初级结果中没有观察到显著的异质性 (I2=11.9%).
在子组中发现了显著的关联:FSH>40U/L的女性,年龄<35岁,以及特定的测试方法 (IIF,DIGFA).
与非卵巢不孕症,健康和低阴性腺控制组相比,观察到更强的关联.

结论:

ANA阳性与POI风险增加有显著联系.
ANA显示出作为早期POI查的血清学标记物的潜力.
建议在35岁以下或FSH>40 IU/L的女性进行常规ANA测试.
进一步的研究应该优化ANA检测方法,标位和模式,以提高准确性.

关键词:

抗核抗体是一种抗核抗体.案例控制研究研究.进行元分析分析.过早的卵巢功能不充分

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